Search AVS

Cutting edge, industry leading technology. Engineered by AVS in Denver, CO, USA, using the highest quality materials and craftsmanship.

Contact Us

Can't find what you need in the FAQ or the instructions?

The easiest way to contact us is through the chat bubble in the bottom right corner of your screen.

See customer pictures and videos, learn, troubleshoot, find a store, or contact us!

Upgrade or maintain your Molecule22 with our parts and accessories!



 Online Owners Manual - Last Updated 3/30/21

WARNING: Failure to read this manual and to observe the proper use of this device could result in damage or injury. Please read this manual or watch the videos on our website for the best experience. We are not liable for legal consequences, damage, or injury due to misuse of this device.


Quick Start Guide

Welcome to the Molecule22, the most advanced oil atomizer ever made! This manual is intended to be a short and simple guide. We strongly recommend that you watch the instructional videos that are easy to understand and more in depth.

We recommend a quick cleaning before use. You can use a cotton swab dipped in isopropyl alcohol to clean the ESCC™ or coil. Make sure not to inhale any alcohol fumes and that the M22 and ESCC or coil are fully dried before use!


Set Up:

M22 Control Tower (AVS Mod):

Screw the Molecule22 onto the mod. Turn on the mod and then based on the heating element installed in the M22, proceed to “ESCC” or “316L SS” mode.

Other mods:

If you are using the flat SS coil, you can use “316”, “316L”, “SS TC”, “TCR” or wattage mode. If you are using the ESCC™, we don't recommend other mods due to the unique electrical properties of the ESCC™ but you can use TCR mode and dial in your TC by adjusting TCR higher if it isn't hot enough and down if it gets too hot. We currently write the TCR we measure on the package.


Preparing the ESCC™:

The ESCC should show ≈ 0.80Ω ±0.40

Refer lower on this page for instructions to install the ESCC™ for the first time. Make sure the ESCC™ is securely installed by pressing down on the middle of the crucible with some gentle pressure. There should be little to no movement in the Zirconia housing. Set your temperature to 500f and 50w. Now heat it up while observing the settings on the screen to ensure everything is working correctly and to sanitize the vaporization surface. Let it cool off.


Preparing the Flat Coil:

The Flat SS coil should show ≈ 0.40Ω ±0.015.

In a dimly lit room, at 15-20 watts apply power to the coil for 1-5 seconds at a time. While doing this, gently poke and strum the coil in different places with the dab tool, until you see any glowing hot spots. As soon as you see the coil start to show a faint glow let go of the power button. Strum and poke the coil a couple more times with light pressure. Repeat this process of firing the coil and then strumming and poking until the coil starts to glow evenly from the middle outward. A very dim red glow is all you need to see. DO NOT overheat the coil or atomizer! If your M22 or mod heats up, give it a break before repeating the process. Risk of burning yourself or damage to the M22 is possible if you overheat it!


First Use & Loading:

Make sure everything is cooled down to room temperature and then take a new resistance reading. To take a new reading with the AVS Mod, navigate the cursor to the “X.XXΩ” value on the screen and select it. Select “Read Again”.

Pop the top off for loading by gripping the top knurled heat sinks and pulling up with a slight twisting motion. We recommend loading about the size of a dry grain of rice. A little bit goes a long way. Overloading will result in poor performance and spillage. Load your oil directly on the center of the coil. If you are using the ESCC™ you can load it anywhere inside the crucible. It is good to lightly warm and pre-melt the oil by pulsing the power button a couple of times before use. Put the top cap back on the housing. Close the air inlet holes in a counterclockwise rotation, opening them up with a clockwise rotation.


Temperature Control Mode

This is the recommended method and applies to both the Flat Oct-Core Coil or ESCC with the M22 Control Tower (AVS Mod). In temp control you will have better flavor and more consistent and predictable vapor production. Certain compounds vaporize at different temperatures. Between about 395°f – 430°f you will vaporize most of the desired compounds and have the best flavor. For the flat coil set the M22 Control Tower to “316L SS” mode, 20-30 watts and 360°-450°f depending on your preference. For the ESCC™ use ESCC mode on the M22 CT, 40-50 watts and 360°-450°f. The ESCC™ can be used in TCR mode on other mods although we only recommend our mod. After some use the base resistance will rise and require a new base resistance reading and TCR adjustments on other mods. If your base (cold resistance) rises more than 0.05 you likely need to clean the spring clip connection or replace the springs. Overloading, or lack of regular cleaning will result in build up or spill over that works its way down into the deck and electrical connections. Regular cleaning will significantly reduce this and lead to much more consistent performance, less spring changes and deep cleans. These things don't impact our mods performance as much either.

To take a puff hold the power button down, wait for about 2-3 seconds and then inhale softly for 6-13 seconds. Continue to inhale for 5-10 seconds after letting off the power button to help cool the ESCC™ and Molecule22 down, vapor is still produced for a few more seconds during cool down. Inhale softly during use as not to create too strong of a vortex inside the M22 creating splatter up.


Wattage mode

Set your regulated mod to run at 20-30 watts with the coil. Higher wattage results in hotter oil, faster. With a higher wattage you will need to take shorter puffs using short pulses or you will overheat the oil. Start at a lower wattage and slowly move up to find what works best for you. If the coil is at room temp, then your first pulse will need to be about 3-6 seconds. After it is warmed up, 1-3 second pulses are all that is needed.


Tips and pointers

  • Pre-Melt your concentrate into the coil or ESCC™ before use to maximize efficiency.
  • Inhale softly during use, the vortex is strong.
  • After you take a puff and let off the fire button, continue to inhale for 5-10 seconds through the device to pull cool air through the M22.
  • Keep the coil or ESCC™ and chamber clean.
  • Swab up excess reclaim after each use.
  • Do not soak in any liquid for excessive amounts of time.
  • Keep the M22 level during use. Excess tilt will make your oil pool up and not vaporize well.
  • Allow the Molecule22 at least 30 seconds or more between puffs to cool back down.
  • Use live concentrates for the best flavor and do not load more than a dry grain of rice.
  • This is an ultra-high efficiency device, a little goes a long way. Small dab = Big cloud & less reclaim
  • Start small and work your way up.
  • Use the Molecule22 responsibly!


Cleaning / Maintenance

It is important to keep your M22 clean. Depending on your level of use, you will need to do a light cleaning daily, to every few days, and a deep cleaning once a week or so. With the ESCC™ we recommend swabbing out the reclaim after every load to every other load. If you allow reclaim to pool up it will lead to splatter. The coil can go a little longer between swabbing due to the coil being able to hold onto some reclaim.

Light clean:

Remove the top cap, warm up the coil or ESCC™ to 450f while you blow on it. Some reclaim will vape off while you do this. Use a dry cotton swab to dab the vaporized oil from around the coil or ESCC™. While the M22 is warm you can use a cotton swab to also clean all around the bowl and coil/ESCC™. Make sure no cotton fibers get left behind as they can burn and affect your flavor.

Deep clean:

Follow the steps for a light clean but dip the cotton swab in 70-91% strength rubbing alcohol. Make sure you are in a ventilated room. With a damp alcohol swab, you can also clean the top cap, ceramic bowl, and other parts.

The ESCC™ can easily be removed for cleaning around it and underneath it by pulling up on it using even and gentle upward pressure. Make sure not to grab the zirconia or ESCC when it is hot! When installing the ESCC™ it is important to install the spring into the deck first, then the zirconia saucer and ESCC™. If there is stubborn build up due to overheating, you can use #0000 Steel wool to scrub it off. You can also soak the ESCC in alcohol as well as the atomizer. When soaking the entire atomizer, remove the 510 pin under the atomizer using a flat head screwdriver so the alcohol can get into this cavity. We recommend not soaking for more than 10 minutes, 30 max. After soaking make sure to fully wipe down the m22 with a paper towel and use swabs to get into the crevices. Let it fully dry before using. We DO NOT recommend torching as it can hurt the gold plating on the legs. After cleaning with alcohol, make sure to wait for it to FULLY dry before using it again.

With proper cleaning and maintenance, a coil can last for months. Although For optimal flavor and performance, we recommend changing the coil every 1-2 weeks with heavy use, every 2-4 weeks with moderate use or 4-8 weeks with light use. The ESCC™ can last many years although the gold plating will wear down and lead to a small increase in resistance. This will only have little impact on performance, and it will still outperform anything in its class even without gold plating.


Installing the Flat SS Coil:

Start with a clean M22. Take it apart, and then loosen the post screws. Place the coil in the ceramic bowl with the legs of the coil going through the holes in the bottom. Cut the legs to about 3-4mm in length and place the coil legs into the post holes of the M22 deck. While pressing down on the coil with your finger or a tool that fits inside the ceramic bowl, tighten the post screws down on the legs of the coil. Make sure the screws are nice and tight on the legs! Then follow the quick start guide for coils.


Installing the ESCC™:

Install the spring clip into the M22 deck with the wider side of the spring parallel with the top and bottom of the AV logo (Fig.1 below).

Use the pointed side of the included dab tool to gently work them down into the post without deforming the clip. Using the dab tool or the screwdriver gently press the sides of the spring clips to make sure they are not snagged and that the ESCC™ will fit in without pushing a tab down, be careful not to push too hard and bend the tabs in, it should be a tight fit with the leg but not take much force to push in. Then place the ESCC™ into the zirconia housing, line up the legs with the spring clips and press down firmly but carefully on the center with even and straight downward force.


Warning / Disclaimers

  • DO NOT use for illegal purposes!!!
  • DO NOT overheat the coil/ESCC or RDA - it can burn you! If your M22 or mod heats up, give it a rest to cool off.
  • DO NOT exceed 60w or 600f, it can damage the Molecule22.
  • DO NOT overload the device. Load as you go. Max ≈0.10g advised.(About a dry grain of rice at a time, or less. This is a high efficiency atomizer.)
  • DO NOT install coils larger than 3mm if they are round. 2.5mm is advised
  • Only recommended for use on mods with batteries that are rated for 20 amps or greater.
  • Always verify that your mod shows the correct ohm for the heating element that is installed.
  • Always make sure the ceramic bowl is flush with the deck when installing a new coil.
  • Keep out of reach from children and minors.


Engineered and tested in Denver, CO, USA, by


Patents pending 

All Rights Reserved © 2019-2021

Advanced Vape Supply